Sources of risk of non-sterility during aseptic handling
| Code | Description |
| A | Air in LAF/SC |
| B | Worktop LAF/SC |
| C | Wall and ceiling LAF/SC |
| D1 | Materials with a sterile surface (tubes, syringes, needles, infusion bags, etc)* |
| D2 | Critical spots† such as the opening of tubes, syringe tips, needles, septa of infusion bags |
| E1 | Materials and equipment with a non-sterile surface (ampoules, vials, bottles, etc)* |
| E2 | Critical spots† such as vial stoppers, ampoule necks |
| F | Operators' hands |
| G | Operators' forearms |
| H | Working procedure |
*For an extensive explanation see Boom et al.22
†A definition of ‘critical spots’ is given in online supplementary file 1.
LAF, laminar airflow cabinet; SC, safety cabinet.