Economic data on closed system drug transfer devices from studies that reported both actual and estimated costs
| Reference | CSTD | Costs | Costs saving | CHEERS criteria | Limitations | ||
| Type | Values | Type | Values | ||||
| Edward et al (2013) USA24 | Phaseal | Acquisition cost | US$106 557/year | Extension of BUD Estimated annual cost | US$96 349 /50 days US$703 047 /year The average waste avoidance per phial was 29% | 10/24 | Acquisition costs and costs per dose not detailed. Conventional system: drugs discarded immediately after first use (overestimates savings). Conflicts of interest: funding from Celgene, Millennium and Seattle Genetics. |
| Barny et al 2015 France25 | Phaseal (compared with conventional system) | Acquisition costs, preparation time, ganciclovir costs | Phaseal: €39.04±37.26 /preparation Conventional system: €34.19±11.39/preparation | Estimated savings by extension of BUD | €4.62 (2 days extension) €11.64/preparation (7 days extension), | 10/24 | Costs not detailed. Conflict of interest: thanks to Becton Dickinson. |
| González-Haba et al 2016 Spain29 | ChemoClave (eight combinations tested) | Acquisition costs, preparation time, estimated annual cost | Between €4.46 and €8.52/dose Between 41.0 and 77.0 s/dose €300000/year | Estimated savings if not all parts of the system are used | €1.03/dose €39069/year | 6/24 | Acquisition costs not detailed. No control group without CSTD. Simulated preparations. Conflicts of interest not specified. |
| Chan et al 2016 Malaysia26 | Phaseal (compared with conventional system) | Acquisition costs (CSTD +other consumables), drug costs, estimated cost per dose, estimated annual cost Estimated costs for conventional system. | Phaseal: US$92072/3 months US$23106/3 months (acquisition costs only) US$40.92/preparation US$368289/year Conventional system: US$83155/3 months US$6988/3 months (acquisition costs only) | Extension of BUD | 10.5% of drug costs | 11/24 | Costs per dose for conventional system not detailed. Conflict of interest: Becton Dickinson provided information. |
BUD, beyond-use date; CHEERS, Consolidated Health Economic Evaluation Reporting Standards; CSTD, closed system transfer device.