Table 3

Dosage accuracy and precision attained after suspending a tablet in 10 mL water and extracting a fraction: 1 mL or 2 mL, a tenth or a fifth of a tablet constituting the intended dose

Direct extractionDirect extractionStirringStirring and pumpingStirring and pumping
Volume extracted1 mL2 mL1 mL1 mL2 mL
Dispersible Aspirin 75 mg98.7±14.5 (80.0–117.3)92.2±13.3 (76.0–113.3)83.4±8.4 (70.7–92)71.1±4.3 (66.7–78.7)72.9±3.1 (69.3–77.3)
Bayer Chewable 81 mg9.3±6.4 (6.2–22.2)12.4±9.6 (4.9–28.4)36.2±39.5 (14.8–116.0)39.9±17.0 (23.5–66.7)34.2±6.6 (23.5–42.0)
Disprin 300 mg45.7±2.6 (43.3–49.9)55.0±3.6 (50.7–60.8)73.4±9.3* (67.2–89.5)89.0±5.3 (80.5–95.8)95.5±2.7 (92.7–98.9)
Aspirin 500 mg3.4±1.1 (2.5–5.6)7.7±4.1 (3.3–14.4)13.0±7.3 (9.2–27.8)43.2±12.4 (20.9–54.1)37.3±21.8 (20.6–79.8)
  • Per cent of intended dose ±SD (lowest–highest value) (n=6) is given. All samples were extracted from zone 2 of the medicine measure.

  • *n=5.