Table 1

Physical and chemical stability of pemetrexed (PXD) concentrate solutions in vials spiked with closed system

Storage temperature (°C)	Vials	Initial drug concentration (mg/mL, n=3)		% initial concentration remaining±SD
Storage temperature (°C)	Vials	Nominal	Actual	Day 1	Day 2	Day 5	Day 6	Day 8	Day 14
22–25	1000 mg/40 mL	25	24.8±0.4	100.1±1.9	102.6±1.0	100.7±1.1	99.6±1.2	98.8±0.4	100.1±0.8
	1000 mg/40 mL	25	24.8±0.4	No browning	Visual browning
	500 mg/20 mL	25	24.8±0.8	100.1±1.5	101.6±2.2	99.9±0.5	98.7±1.1	98.6±0.6	96.7±0.6
	500 mg/20 mL	25	24.8±0.8	No browning	Visual browning
2–8	1000 mg/40 mL	25	24.8±0.4	99.7±0.9	100.6±2.2	103.0±1.0	99.6±1.2	102.5±1.3	101.2±0.8
	1000 mg/40 mL	25	24.8±0.4	No visual browning
	500 mg/20 mL	25	24.8±0.8	101.0±1.4	101.5±1.1	99.7±0.4	98.5±1.3	99.8±1.2	98.6±0.2
	500 mg/20 mL	25	24.8±0.8	No visual browning