Table 1

An overview of measured plasma samples with patient characteristics, therapy duration with LPV/RTV, time between last administrated LPV/RTV dose and measured plasma concentration of LPV/RTV

Patient numberSampleGenderAge (years)Weight (kg)Duration LPV/RTV treatment (days)Time between last dose of LPV/RTV and measurement (hours)Plasma concentration LPV (mg/L)Plasma concentration RTV (mg/L)ConstipationGastric retention
11M57855.510>300.65YesYes
21*M67905.51010.80.19YesYes
22*M67907.512.57.10.28YesYes
31M77736.51019.050.53YesYes
41F65953.510.59.90.20YesYes
51M52994.09.520.10.64YesNo
61*M701024.0929.80.46YesNo
62*M701026.59.523.70.37NoNo
71M651073.011.528.80.53YesNo
81F701292.5119.80.37YesYes
91M52932.09.5>301.05YesYes
101*M501282.59.528.40.52YesNo
102*M501284.510.5>300.44YesNo
111F641042.09.519.71.92YesYes
  • *Samples from same patient, applies for patient number 2, 6 and 10.

  • F, female; LPV, lopinavir; M, male; RTV, ritonavir.