Incidence of ADRs in patients exposed to HCQ and REM
| Characteristics | HCQ patients | REM patients | P value |
| n=101 (%) | n=48 (%) | ||
| Total | 48 (47.5) | 6 (12.5) | <0001 |
| Age, years | |||
| <40–59 | 16/35 (45.7) | 4/16 (25.0) | 0.160 |
| 60–79 | 20/42 (47.6) | 2/25 (8.0) | <0001 |
| ≥80 | 12/24 (50.0) | 0/7 (0.0) | 0.017 |
| Gender | |||
| Male | 28/57 (49.1) | 5/33 (15.2) | 0.001 |
| Female | 20/44 (45.4) | 1/15 (6.7) | 0.006 |
| Coexisting conditions | |||
| Asthma | 2/6 (33.3) | 0/0 (0.0) | |
| Cancer | 6/16 (37.5) | 0/8 (0.0) | |
| Chronic kidney disease | 9/19 (47.4) | 1/1 (100) | |
| Diabetes | 12/32 (37.5) | 2/13 (15.4) | 0.146 |
| HIV/AIDS | 2/6 (33.3) | 1/1 (100) | |
| Hypertension | 27/52 (51.9) | 3/27 (11.1) | <0001 |
| Medication (at baseline) | |||
| ACE inhibitor or ARB | 18/31 (58.1) | 3/23 (13.0) | <0001 |
| Immunosuppressive drugs | 5/9 (55.6) | 0/1 (0.0) | |
| Body mass index | n=86 | n=48 | |
| Normal/underweight | 15/36 (41.7) | 2/28 (7.1) | 0.001 |
| Obese/overweight | 30/50 (60.0) | 4/20 (20.0) | 0.002 |
| Smoking status | n=68 | n=20 | |
| Past smoker | 12/23 (52.2) | 2/7 (28.6) | |
| Smoker | 2/6 (33.3) | 0/2 (0.0) | |
| Never smoked | 21/39 (53.8) | 1/11 (9.1) |
ACE, angiotensin-converting enzyme; ADRs, adverse drug reactions; ARB, angiotensin-receptor blocker; HCQ, hydroxychloroquine ; REM, remdesivir .