Table 3

Examples of medication-related problems and pharmaceutical interventions, University Hospital of Strasbourg, France

MedicationExamples of pharmaceutical interventions
Lopinavir/ritonavir combinationLopinavir/ritonavir 400 mg/100 mg combination was prescribed twice a day in association with azithromycin 500 mg on day 1 (D1) then azithromycin 250 mg D2 to D5. Both medications have the potential for QT prolongation and/or torsade de pointe (possible risk for lopinavir; known for azithromycin). Clinical monitoring by electrocardiogram was recommended and accepted by the physician.
HydroxychloroquineHydroxychloroquine 200 mg twice a day was prescribed to a patient on hydroxyzine 50 mg every evening for sleep disorders. This association is contraindicated due to an increased risk of ventricular rhythm disorders, in particular torsade de pointe. The substitution of hydroxyzine with oxazepam 10 mg every evening was recommended and accepted by the physician.
AzithromycinAzithromycin 500 mg every morning was prescribed for 6 days. According to the marketing authorisation, the recommended dosage was azithromycin 500 mg D1 then azithromycin 250 mg D2 to D5. The overdose was reported to the physician but the prescription was not modified.