Table 1

Summary table

DrugPaperConcentration studiedDiluentsDevicesTemperatureAPI limitsDurationAdditional comments
Amoxicillin7 24Binson et al6 g in 48 mLWater for injectionBaxter SV infuser37°C90%–110%Within 2 hoursNot suitable for continuous infusion
Impact of buffering not investigated
Fawaz et al1000 mg in 70 mL
(co-amoxiclav 1.2 g in 70 mL)
Glucose 5%
Sodium chloride 0.9%
Water for injection
Glass vials37°C90%–110%3.5–4.5 hours
Ampicillin8Nakamura et al12 g in 240 mLSodium chloride 0.9%Baxter LV1031.1°C90%–110%Within 5 hoursNot suitable for continuous infusion
Impact of buffering not investigated
Benzylpenicillin8Nakamura et al14.4 g in 240 mLAcetate Ringers solutionBaxter LV1031.1°C90%–110%24 hoursPotential for extended stability using buffer
Candidate for YCD-compliant stability studies
Cefazolin9 10Metsu et al1 g in 1000 mLSodium chloride 0.9%Ecoflac infusion bags35°C90%–110%48 hoursPotential for extended stability using buffer
Candidate for YCD-compliant stability studies
Akahane et al6 g in 240 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1031.1°C90%–110%At least 24 hours
Cefepime11Ressault et al1 g in 50 mLSodium chloride 0.9%Unspecified33°C90%–110%Up to 12 hoursInsufficient data to support continuous infusion currently; studies to evaluate stability and degradants required.
Cefmetazole9Akahane et al8 g in 240 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1031.1°C90%–110%At least 24 hoursInsufficient data to support continuous infusion currently; studies to evaluate stability and degradants required
Ceftaroline12Al Madfai et al300 mg in 50 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1035°C95%–105%Up to 6 hoursData in elastomeric infusers do not support infusions longer than 6 hours
Ceftolozane–tazobactam13Raby et al300–6000 mg in 240 mLSodium chloride 0.9%Baxter LV1037°C90%–110%24 hoursFor additional information, also see Jamieson et al20
Doripenem9Akahane et al3 g in 240 mLAcetate Ringers solutionBaxter LV1031.1°C90%–110%At least 8 hoursInsufficient data to support continuous infusion currently; studies to evaluate stability and degradants required
Meropenem9 14–16Jamieson et al1–2 g in 48 mLSodium chloride 0.9%Baxter LV1032°C95%–105%Within 6 hoursData in elastomeric infusers do not support infusions longer than 6 hours.
Fawaz et al2 g in 140 mLSodium chloride 0.9%Infusion bags33°C90%–110%Within 5 hoursData in elastomeric infusers do not support infusions longer than 6 hours
Delattre et al1–2 g in 48 mLSodium chloride 0.9%Syringes37°C90%–110%Within 3 hours
Akahane et al3 g in 240 mLSodium chloride 0.9%Baxter LV1031.1°C90%–110%Within 5–6 hours
Piperacillin–tazobactam9 10Metsu et al24 and 48 g in 1000 mLSodium chloride 0.9%Ecoflac infusion bags35°C90%–110%48 hoursFor additional information, also see Jamieson et al20
Akahane et al18 g in 240 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1031.1°C90%–110%At least 24 hours
Voriconazole17Harmanjeet et al200 mg in 100 mLGlucose 5%
Sodium chloride 0.9%
Baxter SV5035°C95%–105%At least 4 hoursPotential for longer stability however unsure of clinical need
  • API, active pharmaceutical ingredient; YCD, Yellow Cover Document.