Table 1

Summary table

DrugPaperConcentration studiedDiluentsDevicesTemperatureAPI limitsDurationAdditional comments
Amoxicillin7 24 Binson et al 6 g in 48 mLWater for injectionBaxter SV infuser37°C90%–110%Within 2 hoursNot suitable for continuous infusion
Impact of buffering not investigated
Fawaz et al 1000 mg in 70 mL
(co-amoxiclav 1.2 g in 70 mL)
Glucose 5%
Sodium chloride 0.9%
Water for injection
Glass vials37°C90%–110%3.5–4.5 hours
Ampicillin8 Nakamura et al 12 g in 240 mLSodium chloride 0.9%Baxter LV1031.1°C90%–110%Within 5 hoursNot suitable for continuous infusion
Impact of buffering not investigated
Benzylpenicillin8 Nakamura et al 14.4 g in 240 mLAcetate Ringers solutionBaxter LV1031.1°C90%–110%24 hoursPotential for extended stability using buffer
Candidate for YCD-compliant stability studies
Cefazolin9 10 Metsu et al 1 g in 1000 mLSodium chloride 0.9%Ecoflac infusion bags35°C90%–110%48 hoursPotential for extended stability using buffer
Candidate for YCD-compliant stability studies
Akahane et al 6 g in 240 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1031.1°C90%–110%At least 24 hours
Cefepime11 Ressault et al 1 g in 50 mLSodium chloride 0.9%Unspecified33°C90%–110%Up to 12 hoursInsufficient data to support continuous infusion currently; studies to evaluate stability and degradants required.
Cefmetazole9 Akahane et al 8 g in 240 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1031.1°C90%–110%At least 24 hoursInsufficient data to support continuous infusion currently; studies to evaluate stability and degradants required
Ceftaroline12 Al Madfai et al 300 mg in 50 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1035°C95%–105%Up to 6 hoursData in elastomeric infusers do not support infusions longer than 6 hours
Ceftolozane–tazobactam13 Raby et al 300–6000 mg in 240 mLSodium chloride 0.9%Baxter LV1037°C90%–110%24 hoursFor additional information, also see Jamieson et al 20
Doripenem9 Akahane et al 3 g in 240 mLAcetate Ringers solutionBaxter LV1031.1°C90%–110%At least 8 hoursInsufficient data to support continuous infusion currently; studies to evaluate stability and degradants required
Meropenem9 14–16 Jamieson et al 1–2 g in 48 mLSodium chloride 0.9%Baxter LV1032°C95%–105%Within 6 hoursData in elastomeric infusers do not support infusions longer than 6 hours.
Fawaz et al 2 g in 140 mLSodium chloride 0.9%Infusion bags33°C90%–110%Within 5 hoursData in elastomeric infusers do not support infusions longer than 6 hours
Delattre et al 1–2 g in 48 mLSodium chloride 0.9%Syringes37°C90%–110%Within 3 hours
Akahane et al 3 g in 240 mLSodium chloride 0.9%Baxter LV1031.1°C90%–110%Within 5–6 hours
Piperacillin–tazobactam9 10 Metsu et al 24 and 48 g in 1000 mLSodium chloride 0.9%Ecoflac infusion bags35°C90%–110%48 hoursFor additional information, also see Jamieson et al 20
Akahane et al 18 g in 240 mLGlucose 5%
Sodium chloride 0.9%
Baxter LV1031.1°C90%–110%At least 24 hours
Voriconazole17 Harmanjeet et al 200 mg in 100 mLGlucose 5%
Sodium chloride 0.9%
Baxter SV5035°C95%–105%At least 4 hoursPotential for longer stability however unsure of clinical need
  • API, active pharmaceutical ingredient; YCD, Yellow Cover Document.