Table 4

Percentage of aciclovir remaining in the Easypump II LT 270–27-S elastomeric infusion device during storage at room temperature and subsequent exposure to in-use temperature of 32°C

Temperature condition	Time (hours)	Mean and SD of percent remaining by initial concentration
		200 mg/240 mL		2400 mg/240 mL		4500 mg/240 mL
		Mean	SD	Mean	SD	Mean	SD
Room temperature (<20°C)	0	100.00	0.00	100.00	0.00	100.00	0.00
	12	99.49	1.23	99.77	0.11	100.38	0.61
	24	99.73	1.03	99.67	0.29	101.54	0.75
	48	100.13	0.36	100.35	0.31	100.55	1.02
	96	100.03	0.65	100.46	0.35	100.18	1.46
	120	99.89	1.02	100.56	0.34	100.94	0.65
	168	100.01	0.99	100.66	0.18	100.74	0.32
	240	99.71	0.61	100.66	0.46	100.51	0.31
	336	99.80	0.66	100.27	0.75	100.13	0.52
In-use temperature (32°C)	344	100.11	1.26	100.16	1.37	82.12	9.31
	348	99.88	1.70	99.99	1.14	69.75	13.80
	360	98.18	2.79	100.26	1.63	39.86	20.30