Table 1

Observed change in pH of aciclovir solution in the Accufuser VAWC0100L elastomeric infusion device during storage at room temperature and subsequent exposure to in-use temperature of 32°C

Temperature condition	Time (hours)	Observed mean±SD pH and change in mean pH from baseline by concentration
		Low concentration		Intermediate concentration		High concentration
		Observed pH	Δ pH	Observed pH	Δ pH	Observed pH	Δ pH
Room temperature (<20°C)	0	10.24±0.01	0.00	11.20±0.00	0.00	11.25±0.01	0.00
	12	10.30±0.01	0.05	11.16±0.04	−0.04	11.25±0.01	0.00
	24	10.27±0.03	0.03	11.08±0.01	−0.12	11.27±0.01	0.01
	48	10.17±0.03	−0.07	11.06±0.00	−0.14	11.22±0.02	−0.03
	96	10.02±0.06	−0.23	10.93±0.02	−0.27	11.25±0.05	−0.01
	120	9.85±0.07	−0.39	10.95±0.03	−0.25	11.15±0.04	−0.11
	168	9.67±0.09	−0.57	10.70±0.04	−0.50	11.04±0.08	−0.21
	240	9.47±0.11	−0.77	10.58±0.03	−0.62	10.94±0.11	−0.31
	336	9.26±0.15	−0.99	10.44±0.03	−0.76	10.88±0.13	−0.37
In-use temperature (32°C)	344	7.43±0.24	−2.81	10.45±0.04	−0.75	10.44±0.05	−0.82
	348	6.91±0.02	−3.33	10.45±0.04	−0.75	10.28±0.09	−0.98
	360	6.86±0.04	−3.38	10.37±0.03	−0.83	10.06±0.21	−1.20