Time point/storage conditions | Side peak 1 (RT about 7.7 min) | Side peak 2 (RT about 8.1 min) | Side peak 3 (RT about 12.2 min) |
Mean % | Mean % | Mean % | |
D0/2–8°C unopened | 0.059 | 2.869 | 0.635 |
D2/2–8°C opened | 0.061 | 3.031 | 1.449 |
D2/25°C opened | 0.052 | 3.003 | 1.436 |
D4/2–8°C opened | 0.050 | 2.887 | 1.380 |
D4/25°C opened | 0.052 | 2.940 | 1.355 |
D8/2–8°C opened | 0.045 | 2.906 | 1.435 |
D8/25°C opened | 0.048 | 2.993 | 1.325 |
D8/2–8°C unopened | 0.043 | 2.923 | 1.450 |
D8/25°C unopened | 0.048 | 3.017 | 1.361 |
*The bevacizumab PF-06439535 peak was determined from triplicate measurements of 3 opened vials at each test condition (D0, D2, D4, D8 at 2–8°C and 25°C, respectively), and for 3 unopened vials for D8 at 2–8°C and 25°C, respectively. Mean % represents the average individual area percentage of the respective side peak compared with the PF-06439535 peak.
D0, day 0 (start); D2, day 2; D4, day 4; D8, day 8; RT, retention time.