Table 3

Summary of Z-average diameter and PdI values

Time point	Storage condition	Z-average, nm	PdI	Main peak, %	Main peak, nm
D0	–	12.08±0.39	0.13±0.04	99.69±0.28	13.00±0.64
D2	2–8°C	11.52±0.26	0.08±0.03	99.40±1.04	12.32±0.45
D2	25°C	11.28±0.08	0.06±0.02	99.40±1.04	11.91±0.28
D4	2–8°C	11.55±0.02	0.05±0.01	100.00±0.00	12.18±0.10
D4	25°C	11.70±0.31	0.08±0.04	100.00±0.00	12.41±0.51
D8	2–8°C	11.41±0.07	0.05±0.02	100.00±0.00	11.94±0.19
	25°C	11.70±0.31	0.08±0.04	100.00±0.00	12.41±0.51
	2–8°C, unopened vial	11.36±0.10*	0.05±0.01	100.00±0.00	11.92±0.15
	25°C, unopened vial	11.54±0.19	0.06±0.03	100.00±0.00	12.11±0.35

PdI values were obtained as mean values from triplicate DLS measurements (main peak (%) deriving from size distribution by volume) for all tested samples and storage conditions.
*Indicates statistically significant difference compared with the respective Z-average value at D0.
D0, day 0 (start); D2, day 2; D4, day 4; D8, day 8; DLS, dynamic light scattering; PdI, polydispersity index.