Elsevier

The Lancet

Volume 351, Issue 9110, 18 April 1998, Page 1178
The Lancet

Research Letters
Pancreatitis after losartan

https://doi.org/10.1016/S0140-6736(05)79122-4Get rights and content

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    Previous population-based case–control studies [33,34] have not supported the hypothesis of the causative effect of antihypertensive medications with ACE inhibitors and ARBs on acute pancreatitis. However, a number of reports showed that ACE inhibitors [35,36] and ARBs [37,38] have been associated with acute pancreatitis, and the mechanisms of acute pancreatitis remain unknown. In the current study, valsartan at 25 mg/kg significantly increased protein concentration of PJ compared with basal level.

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    In the case reported by Bosch,35 enalapril (10 mg/day for 5 months) was discontinued secondary to the development of a chronic cough. In the case reported by Birck et al,36 the patient developed acute pancreatitis, which led to the discontinuation of enalapril (2.5 mg for 5 days) and losartan. After normalization of amylase and lipase levels, both patients were rechallenged with losartan alone.

  • Nitroprusside, ACE Inhibitors, and Other Cardiovascular Agents

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