Abstract
Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
Keywords: Aggregation, self-association, mechanism, nucleation
Current Pharmaceutical Biotechnology
Title: Mechanisms of Protein Aggregation
Volume: 10 Issue: 4
Author(s): John S. Philo and Tsutomu Arakawa
Affiliation:
Keywords: Aggregation, self-association, mechanism, nucleation
Abstract: Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
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Cite this article as:
Philo S. John and Arakawa Tsutomu, Mechanisms of Protein Aggregation, Current Pharmaceutical Biotechnology 2009; 10 (4) . https://dx.doi.org/10.2174/138920109788488932
DOI https://dx.doi.org/10.2174/138920109788488932 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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