Abstract
We report a case of a severe infusion reaction caused by trastuzumab. A 59-year-old woman with metastatic breast cancer was treated with trastuzumab. During the first infusion, initial symptoms such as severe headache and general fatigue developed. Blood pressure fell 90 minutes after these initial symptoms. A collapsed lung was demonstrated by chest X-ray and computed tomography. Steroid therapy was successfully used for these reactions. Careful monitoring of vital signs, examination of the respiratory system, and the use of steroids are recommended for severe infusion reaction.
MeSH terms
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Anaphylaxis / chemically induced*
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Anaphylaxis / drug therapy
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Anaphylaxis / immunology
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Anaphylaxis / therapy
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Anti-Inflammatory Agents / therapeutic use
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Antibodies, Monoclonal / adverse effects*
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents / adverse effects*
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Female
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Glucocorticoids / therapeutic use
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Humans
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / secondary
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Middle Aged
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Pulmonary Atelectasis / chemically induced
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Pulmonary Atelectasis / immunology
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Steroids
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Trastuzumab
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Treatment Outcome
Substances
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Anti-Inflammatory Agents
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antineoplastic Agents
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Glucocorticoids
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Steroids
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Trastuzumab