[Prevalence, indication and compliance with the recommendations of prescription of low molecular weight heparin in oncology]

Bull Cancer. 2015 Nov;102(11):898-905. doi: 10.1016/j.bulcan.2015.09.003. Epub 2015 Oct 21.
[Article in French]

Abstract

Introduction: Venous thromboembolism is a common complication in cancer and is the second cause of death below infection. Low molecular weight heparin is the gold standard in venous thromboembolism during cancer. This work aimed to evaluate the prevalence of prescription of low molecular weight heparin used at curative dose and the compliance of our practices with the recommendations.

Methods: A retrospective study was led over a 3-month period, on adult patients suffering from venous thromboembolism who had received low molecular weight heparin at curative dose.

Results: A 4% prevalence of prescription of low molecular weight heparin at curative doses has been reported. The results showed an incidental discovery of venous thromboembolism on routine restaging scans in 64% cases. The most found indication was the treatment of deep vein thrombosis (51% cases). According to the dosage, overall compliance of prescription is estimated at 55%.

Discussion: The incidental discovery rate (64%) is consistent with the literature that confirms the high incidence of asymptomatic thrombosis. The rate of non-compliant prescriptions could result from a lack of re-evaluation and adjustment of dosages. These results confirm the need to educate practitioners in diagnosing and managing venous thromboembolism.

Keywords: Cancer; Héparine de bas poids moléculaire; Low molecular weight heparin; Thrombose; Thrombosis.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anticoagulants / administration & dosage*
  • Asymptomatic Diseases / epidemiology
  • Asymptomatic Diseases / therapy
  • Drug Prescriptions / standards*
  • Drug Prescriptions / statistics & numerical data
  • Female
  • Guideline Adherence*
  • Heparin, Low-Molecular-Weight / administration & dosage*
  • Humans
  • Incidental Findings
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Retrospective Studies
  • Venous Thromboembolism / drug therapy*
  • Venous Thromboembolism / epidemiology
  • Venous Thromboembolism / etiology
  • Venous Thrombosis / drug therapy

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight