[PDF][PDF] MYO5B mutations cause cholestasis with normal serum gamma‐glutamyl transferase activity in children without microvillous inclusion disease

E Gonzales, SA Taylor, A Davit‐Spraul, A Thébaut… - …, 2017 - Wiley Online Library
Some patients with microvillus inclusion disease due to myosin 5B (MYO5B) mutations may
develop cholestasis characterized by a progressive familial intrahepatic cholestasis‐like …

An update on the physiopathology and therapeutic management of cholestatic pruritus in children

A Thébaut, D Debray, E Gonzales - Clinics and Research in Hepatology …, 2018 - Elsevier
Pruritus is a disabling symptom accompanying chronic cholestasis. In extreme cases, the
refractory nature of pruritus can result in a need for invasive therapies including liver …

Sertraline as an additional treatment for cholestatic pruritus in children

A Thébaut, D Habes, F Gottrand, C Rivet… - Journal of pediatric …, 2017 - Wiley Online Library
Objectives: Pruritus is a severe symptom accompanying chronic cholestasis. It can be
debilitating and difficult to control. In children, first‐line treatments are ursodeoxycholic acid …

Oral tocofersolan corrects or prevents vitamin E deficiency in children with chronic cholestasis

A Thébaut, A Nemeth, J Le Mouhaër… - Journal of pediatric …, 2016 - Wiley Online Library
Objectives: D‐Alpha‐tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop),
has been developed in Europe to provide an orally bioavailable source of vitamin E in …

Pharmacological Premature Termination Codon Readthrough of ABCB11 in Bile Salt Export Pump Deficiency: An In Vitro Study

R Amzal, A Thébaut, M Lapalus, M Almes… - …, 2021 - Wiley Online Library
Background and Aims Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a
severe hepatocellular cholestasis due to biallelic mutations in ABCB11 encoding the …

[HTML][HTML] Targeted-capture next-generation sequencing in diagnosis approach of pediatric cholestasis

…, T Lamireau, A Dabadie, M Bonneton, A Thebaut… - Diagnostics, 2022 - mdpi.com
Background: Cholestasis is a frequent and severe condition during childhood. Genetic
cholestatic diseases represent up to 25% of pediatric cholestasis. Molecular analysis by …

Large-scale screening of lipase acid deficiency in at risk population

…, JM Perarnau, C Pilon, V Ratzlu, A Thebaut… - Clinica Chimica …, 2021 - Elsevier
Background Lysosomal acid lipase deficiency (LALD, OMIM# 278000) is a rare lysosomal
disorder with an autosomal recessive inheritance. The main clinical manifestations are …

[PDF][PDF] Leriche syndrome: treatment with streptokinase and angioplasty

WJ Bean, BA Rodan, AL Thebaut - AJR Am J Roentgenol, 1985 - rotapharm.ge
Discussion Low-dose streptokinase treatment of thromboembolic disease of arteries has
been advocated by numerous authors to open arteries that would otherwise require surgical …

Techniques of extended perfusion using a membrane lung

EC Peirce II, AL Thebaut, BB Kent, JS Kirkland… - The Annals of Thoracic …, 1971 - Elsevier
Nine lightly sedated, chronically instrumented, trained dogs underwent venoarterial bypass
for 5 hours. Three animals bled from the ascending aorta from flow probe erosion and 1 …

Physiopathology and management of cholestatic pruritus in children

A Thébaut, D Debray, E Gonzales - Archives de Pediatrie: Organe …, 2017 - europepmc.org
Pruritus is a disabling symptom accompanying chronic cholestasis. In some cases, refractory
pruritus may require invasive therapies including liver transplantation. The pathogenesis of …