Background Across European countries, differences exist in biosimilar policies, leading to
variations in uptake of biosimilars and divergences in savings all over Europe. Objectives …

To date, no consensus exists among stakeholders about switching patients between
reference biological products (RPs) and biosimilars, which may have been curbing the …

Biologic drugs are highly complex molecules produced by living cells through a multistep
manufacturing process. The key characteristics of these molecules, known as critical quality …

Objective. Recent reports warn that the worldwide cell culture capacity is insufficient to fulfill
the increasing demand for human protein drugs. Production in milk of transgenic animals is …

Pompe's disease is a fatal muscular disorder caused by lysosomal α-glucosidase deficiency.
In an open-label study, four babies with characteristic cardiomyopathy were treated with …

Pompe's disease is an autosomal recessive myopathy. The characteristic lysosomal storage
of glycogen is caused by acid α‐glucosidase deficiency. Patients with late‐onset Pompe's …

Objective To study the effects of addition of spironolactone to angiotensin-converting
enzyme (ACE) inhibition or angiotensin II (AngII) receptor antagonism on proteinuria, blood …

Abstract Background: In Japan, glycyrrhizin therapy is widely used for chronic hepatitis C
and reportedly reduces the progression of liver disease to hepatocellular carcinoma. The …

OBJECTIVE: In Japan, ALT normalization induced by long-term iv glycyrrhizin treatment
reportedly reduces the progression of liver disease to hepatocellular carcinoma in chronic …

Background. The treatment of pediatric patients with drugs in hospitals is being impeded by
a shortage in the availability of licensed drugs in an appropriate formulation. We have …