Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis

MM Gaspar, A Cruz, AF Penha, J Reymão… - International journal of …, 2008 - Elsevier
Tuberculosis (TB) is a leading cause of death amongst infectious diseases. The low
permeation of antimycobacterial agents and their difficult access to infected macrophages …

Lipid nanoparticles containing oryzalin for the treatment of leishmaniasis

R Lopes, CV Eleutério, LMD Gonçalves… - European journal of …, 2012 - Elsevier
Oryzalin is a dinitroaniline drug that has attracted recent interest for the treatment of
leishmaniasis. Its use as an antiparasitic therapeutic agent is limited by the low water …

Ethosomes for enhanced skin delivery of griseofulvin

…, C Vitor, A Guerreiro, C Severino, C Eleutério… - Colloids and Surfaces B …, 2016 - Elsevier
Griseofulvin (GRF) is an important antifungal drug with low bioavailability and, for this
reason, a topical formulation with a targeted action and minimal systemic effects, appears to …

Lycopene from tomatoes: vesicular nanocarrier formulations for dermal delivery

A Ascenso, S Pinho, C Eleutério… - Journal of agricultural …, 2013 - ACS Publications
This experimental work aimed to develop a simple, fast, economic, and environmentally
friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich …

Liposomes versus lipid nanoparticles: comparative study of lipid-based systems as oryzalin carriers for the treatment of leishmaniasis

RM Lopes, MM Gaspar, J Pereira… - Journal of …, 2014 - ingentaconnect.com
Main-stay in treatment of leishmaniasis relies on chemotherapy but none of the current
drugs combines high activity and low toxicity at affordable costs. Dinitroanilines are a new …

[HTML][HTML] Development and mechanistic insight into the enhanced cytotoxic potential of parvifloron D albumin nanoparticles in EGFR-overexpressing pancreatic cancer …

…, P Kumar, V Pillay, YE Choonara, C Eleutério… - Cancers, 2019 - mdpi.com
Pancreatic cancer is one of the most lethal cancers, with an extremely poor prognosis. The
development of more effective therapies is thus imperative. Natural origin compounds …

[HTML][HTML] Topical allopurinol-loaded nanostructured lipid carriers: a novel approach for wound healing management

C Varrica, M Carvalheiro, C Faria-Silva, C Eleutério… - Bioengineering, 2021 - mdpi.com
Nanostructured lipid carriers (NLC) have been widely studied as delivery systems for a
variety of routes, including the skin. Their composition results in an imperfect lipid matrix …

[HTML][HTML] Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management

JO Pinho, M Matias, V Marques, C Eleutério… - Biomedicine & …, 2023 - Elsevier
The aggressiveness of melanoma and lack of effective therapies incite the discovery of
novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene …

[HTML][HTML] Development of parvifloron D-loaded smart nanoparticles to target pancreatic cancer

A Santos-Rebelo, C Garcia, C Eleutério, A Bastos… - Pharmaceutics, 2018 - mdpi.com
Pancreatic cancer is the eighth leading cause of cancer death worldwide. For this reason,
the development of more effective therapies is a major concern for the scientific community …

Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections

RM Lopes, J Pereira, MA Esteves, MM Gaspar… - …, 2016 - Future Medicine
Aim: To improve the potential of trifluralin (TFL) in the management of Leishmania infantum
infections through the synthesis of analogs (TFLA) and incorporation in nanoparticulate drug …