Background During the first wave of the coronavirus disease 2019 (COVID-19) pandemic,
older patients had an increased risk of hospitalisation and death. Reports on the association …

Background Optimizing polypharmacy is often difficult, and critical appraisal of medication
use often leads to one or more changes. We developed the Prescribing Optimization Method …

Methods We studied consecutively hospitalized patients on geriatric wards of the University
Medical Center in Utrecht (n= 105) and of the Tweesteden teaching hospital in Tilburg (n …

Background Falling is a common and serious problem in the elderly. Previous studies
suggest that the use of psychotropic drugs increases the risk of falling. However, the …

Represcription of medication that was withdrawn after the occurrence of an adverse drug
event (including allergy), is a recognized medication safety issue on a patient level. We …

Background Adverse drug reactions (ADRs) are estimated to be the fifth cause of hospital
death. Up to 50% are potentially preventable and a significant number are recurrent …

Objectives A high incidence of delirium has been reported in older patients with Coronavirus
disease 2019 (COVID‐19). We aimed to identify determinants of delirium, including the …

Purpose Older patients with COVID-19 can present with atypical complaints, such as falls or
delirium. In other diseases, such an atypical presentation is associated with worse clinical …

Adverse drug reactions (ADRs) are a common, and often preventable, cause of hospital
admission, especially in the elderly, and can occur during hospitalization. In this current …

Abstract Background: The Netherlands Pharmacovigilance Centre Lareb received four
cases of severe symptomatic hyponatraemia or syndrome of inappropriate antidiuretic …