Microwave‐assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous‐flow transformations

IR Baxendale, CM Griffiths‐Jones… - … A European Journal, 2006 - Wiley Online Library
This article describes the design, optimisation and development of a Suzuki cross‐coupling
protocol mediated by an efficient palladium‐encapsulated catalyst (Pd EnCatTM) under …

Monoacidic inhibitors of the Kelch-like ECH-associated protein 1: nuclear factor erythroid 2-related factor 2 (KEAP1: NRF2) protein–protein interaction with high cell …

TG Davies, WE Wixted, JE Coyle… - Journal of medicinal …, 2016 - ACS Publications
KEAP1 is the key regulator of the NRF2-mediated cytoprotective response, and increasingly
recognized as a target for diseases involving oxidative stress. Pharmacological intervention …

A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

IR Baxendale, J Deeley, CM Griffiths-Jones… - Chemical …, 2006 - pubs.rsc.org
A flow process for the multi-step synthesis of the alkaloid natural product (±)-oxomaritidine is
described, mediated through the use of microfluidic pumping systems that progress material …

Structure–activity and structure–conformation relationships of Aryl propionic acid inhibitors of the kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related …

TD Heightman, JF Callahan, E Chiarparin… - Journal of medicinal …, 2019 - ACS Publications
The KEAP1–NRF2-mediated cytoprotective response plays a key role in cellular
homoeostasis. Insufficient NRF2 signaling during chronic oxidative stress may be …

Discovery of a potent nonpeptidomimetic, small-molecule antagonist of cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP …

E Tamanini, IM Buck, G Chessari… - Journal of Medicinal …, 2017 - ACS Publications
XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key
regulators of anti-apoptotic and pro-survival signaling pathways. Overexpression of IAPs …

Effectiveness of the corrective babbling speech treatment program for children with a history of cleft palate or velopharyngeal dysfunction

C Dobbelsteyn, E Kay-Raining Bird… - The Cleft Palate …, 2014 - journals.sagepub.com
Objective To investigate the effectiveness of a phonetic-based, parent-administered
treatment to reduce cleft-related speech errors. Design Immediate treatment (IT) versus …

Preparation of the neolignan natural product grossamide by a continuous-flow process

IR Baxendale, CM Griffiths-Jones, SV Ley… - Synlett, 2006 - thieme-connect.com
Thieme E-Journals - Synlett / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNLETT Full-text search Full-text search Author …

Fragment-based discovery of a potent, orally bioavailable inhibitor that modulates the phosphorylation and catalytic activity of ERK1/2

TD Heightman, V Berdini, H Braithwaite… - Journal of medicinal …, 2018 - ACS Publications
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers.
Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant …

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1 …

D Norton, WG Bonnette, JF Callahan… - Journal of Medicinal …, 2021 - ACS Publications
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is
increasing interest in developing small-molecule activators of this pathway as therapeutics …

Total synthesis of antascomicin B

DEA Brittain, CM Griffiths‐Jones, MR Linder… - Angewandte …, 2005 - Wiley Online Library
In 1996, a search for novel materials that might elicit similar biological effects to rapamycin
and FK506 was initiated at Sandoz.[1] The immunophilin FKBP12 (the primary target for …