Clinical applications of laser speckle contrast imaging: a review

W Heeman, W Steenbergen… - … of biomedical optics, 2019 - spiedigitallibrary.org
When a biological tissue is illuminated with coherent light, an interference pattern will be
formed at the detector, the so-called speckle pattern. Laser speckle contrast imaging (LSCI) …

[HTML][HTML] The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients

EC Boerma, C Ince - Intensive care medicine, 2010 - Springer
Purpose The clinical use of vasoactive drugs is not only intended to improve systemic
hemodynamic variables, but ultimately to attenuate derangements in organ perfusion and …

[HTML][HTML] Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study

EC Boerma, KR Mathura, PHJ van der Voort… - Critical care, 2005 - Springer
Introduction The introduction of orthogonal polarization spectral (OPS) imaging in clinical
research has elucidated new perspectives on the role of microcirculatory flow abnormalities …

Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care …

C Ince, EC Boerma, M Cecconi, D De Backer… - Intensive care …, 2018 - Springer
Purpose Hand-held vital microscopes (HVMs) were introduced to observe sublingual
microcirculatory alterations at the bedside in different shock states in critically ill patients …

Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis

EC Boerma, PHJ van der Voort, PE Spronk… - Critical care …, 2007 - journals.lww.com
Objective: To evaluate the relation between sublingual and intestinal microcirculatory
alterations in patients with abdominal sepsis. Design: Prospective observational study …

Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind …

EC Boerma, M Koopmans, A Konijn… - Critical care …, 2010 - journals.lww.com
Objectives: Microcirculatory alterations have been associated with morbidity and mortality in
human sepsis. Such alterations occur despite pressure-guided resuscitation. Earlier data …

[HTML][HTML] Microcirculatory blood flow as a tool to select ICU patients eligible for fluid therapy

A Pranskunas, M Koopmans, PM Koetsier… - Intensive care …, 2013 - Springer
Purpose The aim of this study is to assess the incidence of sublingual microcirculatory flow
alterations, according to a predefined arbitrary cutoff value, in patients with “clinical signs of …

Central venous-arterial pCO2 difference as a tool in resuscitation of septic patients

PA van Beest, MC Lont, ND Holman, B Loef… - Intensive care …, 2013 - Springer
Purpose To investigate the interchangeability of mixed and central venous-arterial carbon
dioxide differences and the relation between the central difference (p CO 2 gap) and cardiac …

[HTML][HTML] Current use of vasopressors in septic shock

TWL Scheeren, J Bakker, D De Backer, D Annane… - Annals of intensive …, 2019 - Springer
Background Vasopressors are commonly applied to restore and maintain blood pressure in
patients with sepsis. We aimed to evaluate the current practice and therapeutic goals …

International study on microcirculatory shock occurrence in acutely ill patients

NAR Vellinga, EC Boerma, M Koopmans… - Critical care …, 2015 - journals.lww.com
Objectives: Microcirculatory alterations are associated with adverse outcome in subsets of
critically ill patients. The prevalence and significance of microcirculatory alterations in the …