The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves
enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) …

Recent research in the area of carbohydrate food ingredients has shown the efficiency of
oligosaccharides when they are used as prebiotics or biopreservatives. Considering the …

During the biogenesis of bacterial cell-wall polysaccharides, such as peptidoglycan,
cytoplasmic synthesized precursors should be trafficked across the plasma membrane. This …

Targeted covalent inhibitors have become an integral part of a number of therapeutic
protocols and are the subject of intense research. The mechanism of action of these …

Colicin M was earlier demonstrated to provoke Escherichia coli cell lysis via inhibition of cell
wall peptidoglycan (murein) biosynthesis. As the formation of the O-antigen moiety of …

Undecaprenyl phosphate is the essential lipid involved in the transport of hydrophilic motifs
across the bacterial membranes during the synthesis of cell wall polymers such as …

Genes encoding proteins that exhibit similarity to the C-terminal domain of Escherichia coli
colicin M were identified in the genomes of some Pseudomonas species, namely, P …

Peptidoglycan is an essential component of the bacterial cell wall, and enzymes involved in
its biosynthesis represent validated targets for antibacterial drug discovery. MurF catalyzes …

The misuse of antibiotics during the last decades led to the emergence of multidrug resistant
pathogenic bacteria. This phenomenon constitutes a major public health issue …

Formation of the peptidoglycan stem pentapeptide requires the insertion of both l and d
amino acids by the ATP-dependent ligase enzymes MurC,-D,-E, and-F. The stereochemical …