[HTML][HTML] Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics

MA Mensink, HW Frijlink… - Carbohydrate …, 2015 - Elsevier
Inulin, a fructan-type polysaccharide, consists of (2→ 1) linked β-d-fructosyl residues (n= 2–
60), usually with an (1↔ 2) α-d-glucose end group. The applications of inulin and its …

[HTML][HTML] How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions

MA Mensink, HW Frijlink… - European Journal of …, 2017 - Elsevier
This review aims to provide an overview of current knowledge on stabilization of proteins by
sugars in the solid state in relation to stress conditions commonly encountered during drying …

Dry powder inhalers for pulmonary drug delivery

HW Frijlink, AH De Boer - Expert opinion on drug delivery, 2004 - Taylor & Francis
The pulmonary route is an interesting route for drug administration, both for effective local
therapy (asthma, chronic obstructive pulmonary disease or cystic fibrosis) and for the …

Dry powder inhalation: past, present and future

AH de Boer, P Hagedoorn, M Hoppentocht… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma
and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked …

Pulmonary delivery of an inulin-stabilized influenza subunit vaccine prepared by spray-freeze drying induces systemic, mucosal humoral as well as cell-mediated …

JP Amorij, V Saluja, AH Petersen, WLJ Hinrichs… - Vaccine, 2007 - Elsevier
In this study pulmonary vaccination with a new influenza subunit vaccine powder was
evaluated. Vaccine powder was produced by spray-freeze drying (SFD) using the …

Which shape factor (s) best describe granules?

AM Bouwman, JC Bosma, P Vonk, JHA Wesselingh… - Powder Technology, 2004 - Elsevier
This study evaluates methods used for granule shape characterization. The aim is to identify
an optimal combination of shape factors to measure granule shape and roughness …

Unraveling protein stabilization mechanisms: Vitrification and water replacement in a glass transition temperature controlled system

N Grasmeijer, M Stankovic, H de Waard… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The aim of this study was to elucidate the role of the two main mechanisms used to explain
the stabilization of proteins by sugar glasses during drying and subsequent storage: the …

Application of process analytical technology in tablet process development using NIR spectroscopy: Blend uniformity, content uniformity and coating thickness …

JJ Moes, MM Ruijken, E Gout, HW Frijlink… - International journal of …, 2008 - Elsevier
Near-infrared (NIR) spectroscopy was employed as a process analytical technique in three
steps of tabletting process: to monitor the blend homogeneity, evaluate the content …

[HTML][HTML] Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications

MA Mensink, HW Frijlink… - Carbohydrate …, 2015 - Elsevier
Inulin is a flexible oligosaccharide which has been used primarily in food for decades.
Recently new applications in the pharmaceutical arena were described. In a previous review …

Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization

M Stanković, HW Frijlink, WLJ Hinrichs - Drug Discovery Today, 2015 - Elsevier
Highlights•We describe the principles of hot melt extrusion technology and its application in
drug delivery.•We highlight several, common biodegradable and nonbiodegradable …