Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …

Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …

Noonan and LEOPARD syndromes are developmental disorders with overlapping features,
including cardiac abnormalities, short stature and facial dysmorphia. Increased RAS …

Background The implantable cardioverter-defibrillator (ICD) may be associated with a high
risk of complications in patients with catecholaminergic polymorphic ventricular tachycardia …

Background—Hypertrophic cardiomyopathy (HCM) is the most common genetic heart
disease characterized by a diverse clinical and phenotypic spectrum. This study reports the …

Background—Myocardial late gadolinium enhancement (LGE) on contrast-enhanced
magnetic resonance imaging (CE-MRI) of patients with hypertrophic cardiomyopathy (HCM) …

OBJECTIVE To determine the influence of a positive genetic test for hypertrophic
cardiomyopathy (HCM) on clinical outcome. PATIENTS AND METHODS A cohort of 203 …

Calcium channel blockers (CCBs) have the ability to inhibit contractility in smooth muscle
cells. CCBs have an already established role in the treatment of non-pregnant hypertension …

This paper examines the benefits and costs of Job Training Partnership Act (JTPA) Title II-A
programs for economically disadvantaged adults and out-of-school youths. It is based on a …

Objectives: The aim of this study was to determine the efficacy of implantable cardioverter-
defibrillators (ICDs) in children and adolescents with hypertrophic cardiomyopathy (HCM) …