Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy
JM Bos, JA Towbin, MJ Ackerman - Journal of the American College of …, 2009 - jacc.org
Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …
[HTML][HTML] Truncations of titin causing dilated cardiomyopathy
…, A Di Lenarda, G Sinagra, JM Bos… - … England Journal of …, 2012 - Mass Medical Soc
Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
…, W Schackwitz, A Ustaszewska, A Landstrom, JM Bos… - Nature …, 2007 - nature.com
Noonan and LEOPARD syndromes are developmental disorders with overlapping features,
including cardiac abnormalities, short stature and facial dysmorphia. Increased RAS …
including cardiac abnormalities, short stature and facial dysmorphia. Increased RAS …
Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: a systematic review
TM Roston, K Jones, NM Hawkins, JM Bos… - Heart Rhythm, 2018 - Elsevier
Background The implantable cardioverter-defibrillator (ICD) may be associated with a high
risk of complications in patients with catecholaminergic polymorphic ventricular tachycardia …
risk of complications in patients with catecholaminergic polymorphic ventricular tachycardia …
Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy
MS Maron, JJ Finley, JM Bos, TH Hauser… - Circulation, 2008 - Am Heart Assoc
Background—Hypertrophic cardiomyopathy (HCM) is the most common genetic heart
disease characterized by a diverse clinical and phenotypic spectrum. This study reports the …
disease characterized by a diverse clinical and phenotypic spectrum. This study reports the …
Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance imaging in patients with hypertrophic …
…, PA Araoz, MJ Ackerman, P Sorajja, JM Bos… - Circulation: Heart …, 2010 - Am Heart Assoc
Background—Myocardial late gadolinium enhancement (LGE) on contrast-enhanced
magnetic resonance imaging (CE-MRI) of patients with hypertrophic cardiomyopathy (HCM) …
magnetic resonance imaging (CE-MRI) of patients with hypertrophic cardiomyopathy (HCM) …
Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy
…, F Girolami, MJ Ackerman, S Nistri, JM Bos… - Mayo Clinic …, 2008 - Elsevier
OBJECTIVE To determine the influence of a positive genetic test for hypertrophic
cardiomyopathy (HCM) on clinical outcome. PATIENTS AND METHODS A cohort of 203 …
cardiomyopathy (HCM) on clinical outcome. PATIENTS AND METHODS A cohort of 203 …
Calcium channel blockers in the management of preterm labor and hypertension in pregnancy
DNM Papatsonis, CAR Lok, JM Bos… - European Journal of …, 2001 - Elsevier
Calcium channel blockers (CCBs) have the ability to inhibit contractility in smooth muscle
cells. CCBs have an already established role in the treatment of non-pregnant hypertension …
cells. CCBs have an already established role in the treatment of non-pregnant hypertension …
The benefits and costs of JTPA Title II-A programs: Key findings from the National Job Training Partnership Act study
…, SH Bell, G Cave, F Doolittle, W Lin, JM Bos - Journal of human …, 1997 - JSTOR
This paper examines the benefits and costs of Job Training Partnership Act (JTPA) Title II-A
programs for economically disadvantaged adults and out-of-school youths. It is based on a …
programs for economically disadvantaged adults and out-of-school youths. It is based on a …
Prevention of sudden cardiac death with implantable cardioverter-defibrillators in children and adolescents with hypertrophic cardiomyopathy
…, F Formisano, E Devoto, A Anastasakis, JM Bos… - Journal of the American …, 2013 - jacc.org
Objectives: The aim of this study was to determine the efficacy of implantable cardioverter-
defibrillators (ICDs) in children and adolescents with hypertrophic cardiomyopathy (HCM) …
defibrillators (ICDs) in children and adolescents with hypertrophic cardiomyopathy (HCM) …