[PDF][PDF] A living biobank of breast cancer organoids captures disease heterogeneity
…, G Bounova, F Weeber, AV Balgobind, K Wind… - Cell, 2018 - cell.com
Breast cancer (BC) comprises multiple distinct subtypes that differ genetically,
pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of …
pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of …
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases
X Xiang, K Wind, T Wiedemann, T Blume… - Science translational …, 2021 - science.org
2-Deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
…, MA Vogt, E Weidinger, L Riedl, K Wind… - The EMBO …, 2022 - embopress.org
Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …
[HTML][HTML] The clinical value of measuring circulating HPV DNA during chemo-radiotherapy in squamous cell carcinoma of the anus
AC Lefèvre, N Pallisgaard, C Kronborg, KL Wind… - Cancers, 2021 - mdpi.com
Simple Summary Anal cancer is treated with high dose chemoradiotherapy; but despite this,
a minor patient group experience treatment failure. Anal cancer is strongly related to human …
a minor patient group experience treatment failure. Anal cancer is strongly related to human …
[HTML][HTML] Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
…, JA Harris, S Hummel, J Gnörich, K Wind… - Molecular …, 2022 - Springer
Background Genetic mutations underlying familial Alzheimer's disease (AD) were identified
decades ago, but the field is still in search of transformative therapies for patients. While …
decades ago, but the field is still in search of transformative therapies for patients. While …
Primary hepatic leiomyosarcoma in adults: analysis of prognostic factors
M Chi, AZ Dudek, KP Wind - Oncology Research and Treatment, 2012 - karger.com
Primary hepatic leiomyosarcoma (LMS) is a rare malignancy of the liver in adults, with
variable overall survival (OS). The main purpose of this study was to identify prognostic …
variable overall survival (OS). The main purpose of this study was to identify prognostic …
Loss of TMEM 106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice
Single nucleotide polymorphisms (SNP s) in TMEM 106B encoding the lysosomal type II
transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) …
transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) …
[HTML][HTML] [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data
…, C Klaus, L Vogler, S Katzdobler, K Wind… - Journal of …, 2023 - Springer
Objectives Reactive gliosis is a common pathological hallmark of CNS pathology resulting
from neurodegeneration and neuroinflammation. In this study we investigate the capability of …
from neurodegeneration and neuroinflammation. In this study we investigate the capability of …
[HTML][HTML] Depletion and activation of microglia impact metabolic connectivity of the mouse brain
J Gnörich, A Reifschneider, K Wind, A Zatcepin… - Journal of …, 2023 - Springer
Aim We aimed to investigate the impact of microglial activity and microglial FDG uptake on
metabolic connectivity, since microglial activation states determine FDG–PET alterations …
metabolic connectivity, since microglial activation states determine FDG–PET alterations …
[HTML][HTML] Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation
…, F Peters, K Ochs, C Focke, C Sacher, K Wind… - Theranostics, 2021 - ncbi.nlm.nih.gov
Modulation of the innate immune system is emerging as a promising therapeutic strategy
against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect …
against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect …