[PDF][PDF] A living biobank of breast cancer organoids captures disease heterogeneity

…, G Bounova, F Weeber, AV Balgobind, K Wind… - Cell, 2018 - cell.com
Breast cancer (BC) comprises multiple distinct subtypes that differ genetically,
pathologically, and clinically. Here, we describe a robust protocol for long-term culturing of …

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

X Xiang, K Wind, T Wiedemann, T Blume… - Science translational …, 2021 - science.org
2-Deoxy-2-[18F] fluoro-d-glucose positron emission tomography (FDG-PET) is widely used
to study cerebral glucose metabolism. Here, we investigated whether the FDG-PET signal is …

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

…, MA Vogt, E Weidinger, L Riedl, K Wind… - The EMBO …, 2022 - embopress.org
Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …

[HTML][HTML] The clinical value of measuring circulating HPV DNA during chemo-radiotherapy in squamous cell carcinoma of the anus

AC Lefèvre, N Pallisgaard, C Kronborg, KL Wind… - Cancers, 2021 - mdpi.com
Simple Summary Anal cancer is treated with high dose chemoradiotherapy; but despite this,
a minor patient group experience treatment failure. Anal cancer is strongly related to human …

[HTML][HTML] Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

…, JA Harris, S Hummel, J Gnörich, K Wind… - Molecular …, 2022 - Springer
Background Genetic mutations underlying familial Alzheimer's disease (AD) were identified
decades ago, but the field is still in search of transformative therapies for patients. While …

Primary hepatic leiomyosarcoma in adults: analysis of prognostic factors

M Chi, AZ Dudek, KP Wind - Oncology Research and Treatment, 2012 - karger.com
Primary hepatic leiomyosarcoma (LMS) is a rare malignancy of the liver in adults, with
variable overall survival (OS). The main purpose of this study was to identify prognostic …

Loss of TMEM 106B potentiates lysosomal and FTLD‐like pathology in progranulin‐deficient mice

G Werner, M Damme, M Schludi, J Gnörich, K Wind… - EMBO …, 2020 - embopress.org
Single nucleotide polymorphisms (SNP s) in TMEM 106B encoding the lysosomal type II
transmembrane protein 106B increase the risk for frontotemporal lobar degeneration (FTLD) …

[HTML][HTML] [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data

…, C Klaus, L Vogler, S Katzdobler, K Wind… - Journal of …, 2023 - Springer
Objectives Reactive gliosis is a common pathological hallmark of CNS pathology resulting
from neurodegeneration and neuroinflammation. In this study we investigate the capability of …

[HTML][HTML] Depletion and activation of microglia impact metabolic connectivity of the mouse brain

J Gnörich, A Reifschneider, K Wind, A Zatcepin… - Journal of …, 2023 - Springer
Aim We aimed to investigate the impact of microglial activity and microglial FDG uptake on
metabolic connectivity, since microglial activation states determine FDG–PET alterations …

[HTML][HTML] Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation

…, F Peters, K Ochs, C Focke, C Sacher, K Wind… - Theranostics, 2021 - ncbi.nlm.nih.gov
Modulation of the innate immune system is emerging as a promising therapeutic strategy
against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect …