Hypromellose–A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery

E Mašková, K Kubová, BT Raimi-Abraham… - Journal of controlled …, 2020 - Elsevier
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional
pharmaceutical excipient widely exploited in oral sustained drug release matrix systems …

[PDF][PDF] Biological role of copper as an essential trace element in the human organism. Biologická role mědi jako základního stopového prvku v lidském organismu

M Pavelková, J Vysloužil, K Kubová, D Vetchý - Ceska Slov Farm, 2018 - prolekare.cz
This paper presents an overview of the physiological properties of copper (Cu), an essential
trace element playing an important role in the human metabolism, primarily as a cofactor of …

[HTML][HTML] A critical overview of FDA and EMA statistical methods to compare in vitro drug dissolution profiles of pharmaceutical products

J Muselík, A Komersová, K Kubová, K Matzick… - Pharmaceutics, 2021 - mdpi.com
A drug dissolution profile is one of the most critical dosage form characteristics with
immediate and controlled drug release. Comparing the dissolution profiles of different …

[HTML][HTML] Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions

L Kursvietiene, DM Kopustinskiene, I Staneviciene… - Antioxidants, 2023 - mdpi.com
Cancer is one of the most serious public health issues worldwide, demanding ongoing
efforts to find novel therapeutic agents and approaches. Amid growing interest in the …

Self-emulsifying drug delivery systems: In vivo evaluation of their potential for oral vaccination

N Lupo, VN Tkadlečková, M Jelkmann, F Laffleur… - Acta Biomaterialia, 2019 - Elsevier
Oral Immunization remains a challenge as antigens are rapidly metabolized in the
gastrointestinal tract. In numerous previous studies, Self-emulsifying drug delivery systems …

[HTML][HTML] Highly soluble drugs directly granulated by water dispersions of insoluble Eudragit® polymers as a part of hypromellose k100m matrix systems

E Mašková, M Naiserová, K Kubová, J Mašek… - BioMed research …, 2019 - hindawi.com
The aim of the present study was to investigate the suitability of insoluble Eudragit® water
dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble …

(Meth) acrylate copolymers of Eudragit® type in oral tablet technology.

M Naiserová, K Kubová, J Vysloužil… - Ceska a Slovenska …, 2019 - europepmc.org
This review focuses on the characterization of (meth) acrylate copolymers-Eudragit®,
describing their thermal treatment behaviour, possible interactions between cationic and …

[HTML][HTML] Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study

T Bílik, J Vysloužil, M Naiserová, J Muselík… - Pharmaceutics, 2022 - mdpi.com
Modern pharmaceutical technology still seeks new excipients and investigates the further
use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 …

[HTML][HTML] Assessment of antimicrobic, antivirotic and cytotoxic potential of alginate beads cross-linked by bivalent ions for vaginal administration

M Pavelková, J Vysloužil, K Kubová, S Pavloková… - Pharmaceutics, 2021 - mdpi.com
Antimicrobial agent abuse poses a serious threat for future pharmacotherapy, including
vaginal administration. The solution can be found in simple polymeric systems with inherent …

Clinical testing of antiretroviral drugs as a future prevention against vaginal and rectal transmission of HIV infection–review of currently available results

J Vysloužil, K Kubová… - Acta …, 2019 - hrcak.srce.hr
Sažetak The original purpose of vaginally applied microbicides was to slow down the HIV
epidemic among the population until an effective vaccination was developed. Nowadays …