Children frequently receive medicines that are designed for adults. The dose of
commercially available products is adapted, mostly based on the child's bodyweight, thereby …

In the past decades, new cancer treatments have been introduced in pediatric oncology
leading to improvement in clinical outcomes and survival rates. However, due to inter …

There is a need for information on the bioavailability in pediatric patients of drugs from
manipulated dosage forms when applied in combination with food and/or co-medication …

In recent years new targeted small molecule kinase inhibitors have become available for
pediatric patients with cancer. Relationships between drug exposure and treatment …

Evidence on the clinical effectiveness of probiotics in the prevention of necrotising
enterocolitis (NEC) in preterm infants is conflicting and cohort studies lacked adjustment for …

Aim Due to a lack of age‐appropriate formulations, administration of drugs to children
remains a challenge. This study aimed to identify the problems experienced in both the …

Intravenous use of the calcium-channel blocker nicardipine a... : Journal of Hypertension
Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe …

Objective To investigate the functional reactivity of 5-hydroxytryptamine (serotonin; 5-HT)
receptors in foetal umbilical cord arteries (UCA) and maternal subcutaneous fat resistance …

Introduction Many drugs are unavailable in suitable oral paediatric dosage forms, and
pharmacists often have to compound drugs to provide paediatric patients with an acceptable …

Background Pediatric drug development is hampered by practical, ethical, and scientific
challenges. Microdosing is a promising new method to obtain pharmacokinetic data in …