Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

The microstructure and mechanical behavior of simple product geometries produced by
layered manufacturing using the electron beam melting (EBM) process and the selective …

Background Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce
cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk with high …

Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The
structure and absolute configuration of mevinolini and its open acid form, mevinolinic acid …

Although small GTP-binding proteins of the Rho family have been implicated in signaling to
the actin cytoskeleton, the exact nature of the linkage has remained obscure. We describe a …

Otto Warburg's theory on the origins of cancer postulates that tumor cells have defects in
mitochondrial oxidative phosphorylation and therefore rely on high levels of aerobic …

Background Both the prevalence and mortality attributable to chronic obstructive pulmonary
disease (COPD) seem to be increasing in low-income and middle-income countries, but few …

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …