Background Fluoropyrimidines are antineoplastic drugs used for the treatment of many types
of solid tumours. Approximately 80%–90% administered are metabolised by the enzyme …

Objectives To assess the effectiveness of the antiinterleukin-6 receptor monoclonal antibody
tocilizumab in patients with moderate-to-severe Graves' orbitopathy (GO) in clinical practice …

Background Imiquimod is an immunomodulator, with antitumour activity, indicated for the
treatment of genital and perianal warts produced by the human papilloma virus (HPV) …

Background Fampridine is indicated to improve walking in adult patients with multiple
sclerosis (MS) and an expanded disability status scale (EDSS) score of 4–7. In order to …

Background Degludec is a new-generation basal insulin analogue with a longer acting,
better pharmacokynetic and pharmacodynamic profile and with four times less variability …

Background Restricting the use of antibiotics at the hospital level is part of the rational use of
these agents. Through a multidisciplinary process, their use is restricted to certain groups of …