OBJECTIVES: As the role of polymorphisms in death receptors (DRs) such as Tumor
Necrosis Factor–related Apoptosis-inducing Ligand Receptor 1 (TRAIL-R1) and Tumor …

Background. The production of anti-drug antibodies (ADAs) against IgG monoclonal
antibodies (mAbs) targeting tumour necrosis factor (TNF) is an important cause of loss of …

Besides the therapeutic effect of infliximab by the blocking of soluble tumour necrosis factor
(TNF), current evidence indicates that membrane-bound TNF is also a target of infliximab …

Background: The introduction of anti–tumor necrosis factor α (anti-TNFα) drugs has
improved the clinical outcomes in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) …

Objective To determine persistence of treatment with secukinumab across its different
indications. Method This is a retrospective descriptive observational study including adult …

Abstract Objective Dual PEGylated interferon-α (PEG-IFN) and ribavirin therapy has been
the main hepatitis C virus (HCV) treatment of the last decade. Current direct-acting antiviral …

Background The use of drugs during pregnancy is always controversial. There is limited
information about the use of infliximab during pregnancy. Purpose To describe the …

Background Behçet's disease (BD) is a rheumatic disease characterised by polyarthritis,
urogenital ulcers, uveitis, cutaneous lesions, alterations in the central nervous system and …

Background Since 1981, the year of the first case of infection with HIV/AIDS, about 60 million
people have been infected with the virus, and some 20 million have died. But since the …

Background Idiopathic thrombocytopenic purpura (ITP) is a disease characterised by
decreased platelet count. Romiplostim and eltrombopag are thrombopoietin receptor …