The question of how animal studies should be designed, conducted, and analyzed remains
underexposed in societal debates on animal experimentation. This is not only a scientific but …

With the release of the landmark report Toxicity Testing in the 21st Century: A Vision and a
Strategy, the US National Academy of Sciences, in 2007, precipitated a major change in the …

Systematic reviews, pioneered in the clinical field, provide a transparent, methodologically
rigorous and reproducible means of summarizing the available evidence on a precisely …

Assessments of methodological and reporting quality are critical to adequately judging the
credibility of a study's conclusions and to gauging its potential reproducibility. To aid those …

Based on existing data and previous work, a series of studies is proposed as a basis toward
a pragmatic early step in transforming toxicity testing. These studies were assembled into a …

This is the report of the eleventh of a series of workshops organised by the European Centre
for the Validation of Alternative Methods (ECV AM), which was established in 1991 by the …

Since March 2013, animal use for cosmetics testing for the European market has been
banned. This requires a renewed view on risk assessment in this field. However, in other …

This year marks the 60 th anniversary of Russell and Burch's pioneering book, The
Principles of Humane Experimental Technique. Their 3Rs framework has helped to inspire …

Validation of new approaches in regulatory toxicology is commonly defined as the
independent assessment of the reproducibility and relevance (the scientific basis and …

Abstract The Evidence-based Toxicology Collaboration hosted a workshop on “The
Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology,” …