Conditional Müller cell ablation causes independent neuronal and vascular pathologies in a novel transgenic model
Müller cells are the major glia of the retina that serve numerous functions essential to retinal
homeostasis, yet the contribution of Müller glial dysfunction to retinal diseases remains …
homeostasis, yet the contribution of Müller glial dysfunction to retinal diseases remains …
Patient-centred management of polypharmacy: a process for practice
NL Barnett, L Oboh, K Smith - European Journal of Hospital …, 2016 - ejhp.bmj.com
Medicines are the most common intervention to improve health. The number of medicines
taken by older people in the UK has been steadily increasing for the last three decades …
taken by older people in the UK has been steadily increasing for the last three decades …
[DOC][DOC] Beyond market segmentation
NL Barnett - Harvard Business Review, 1969 - ximb.ac.in
This article reviews the various segmentation techniques used by consumer marketing
companies for new product development. In noting that each approach offers advantages for …
companies for new product development. In noting that each approach offers advantages for …
Intravitreal drug delivery in retinal disease: are we out of our depth?
Introduction: With the ever-increasing global burden of retinal disease, there is an urgent
need to vastly improve formulation strategies that enhance posterior eye delivery of …
need to vastly improve formulation strategies that enhance posterior eye delivery of …
Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model
PE Rakoczy, D Zhang, T Robertson, NL Barnett… - The American journal of …, 2002 - Elsevier
Age-related macular degeneration (AMD) is the major cause of blindness in the developed
world. Its pathomechanism is unknown and its late onset, complex genetics and strong …
world. Its pathomechanism is unknown and its late onset, complex genetics and strong …
Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina
DV Pow, NL Barnett - Neuroscience letters, 2000 - Elsevier
Excitatory amino acid transporter 5 (EAAT5) is a retina-specific glutamate transporter which
has an associated chloride conductance. Thus it is comparable in its functional properties to …
has an associated chloride conductance. Thus it is comparable in its functional properties to …
[HTML][HTML] Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys
CM Lai, WY Shen, M Brankov, YKY Lai, NL Barnett… - Molecular Therapy, 2005 - cell.com
Vascular endothelial growth factor (VEGF) is one of the major mediators of retinal ischemia-
associated neovascularization. We have shown here that adeno-associated virus (AAV) …
associated neovascularization. We have shown here that adeno-associated virus (AAV) …
An open-label, noncomparative study of miglustat in type I Gaucher disease: efficacy and tolerability over 24 months of treatment
GM Pastores, NL Barnett, EH Kolodny - Clinical therapeutics, 2005 - Elsevier
BACKGROUND:: The substrate synthesis inhibitor miglustat (N-butyldeoxynojirimycin) is the
first oral agent to receive regulatory approval for the treatment of type I Gaucher disease …
first oral agent to receive regulatory approval for the treatment of type I Gaucher disease …
[HTML][HTML] Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration
R Natoli, N Fernando, H Jiao, T Racic… - … & visual science, 2017 - tvst.arvojournals.org
Purpose: Complement system dysregulation is strongly linked to the progression of age-
related macular degeneration (AMD). Deposition of complement including C3 within the …
related macular degeneration (AMD). Deposition of complement including C3 within the …
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype
H Quek, J Luff, KG Cheung, S Kozlov… - Human molecular …, 2017 - academic.oup.com
Abstract Ataxia-telangiectasia (AT), an autosomal recessive disease caused by mutations in
the ATM gene is characterised by cerebellar atrophy and progressive neurodegeneration …
the ATM gene is characterised by cerebellar atrophy and progressive neurodegeneration …