Conditional Müller cell ablation causes independent neuronal and vascular pathologies in a novel transgenic model

W Shen, M Fruttiger, L Zhu, SH Chung… - Journal of …, 2012 - Soc Neuroscience
Müller cells are the major glia of the retina that serve numerous functions essential to retinal
homeostasis, yet the contribution of Müller glial dysfunction to retinal diseases remains …

Patient-centred management of polypharmacy: a process for practice

NL Barnett, L Oboh, K Smith - European Journal of Hospital …, 2016 - ejhp.bmj.com
Medicines are the most common intervention to improve health. The number of medicines
taken by older people in the UK has been steadily increasing for the last three decades …

[DOC][DOC] Beyond market segmentation

NL Barnett - Harvard Business Review, 1969 - ximb.ac.in
This article reviews the various segmentation techniques used by consumer marketing
companies for new product development. In noting that each approach offers advantages for …

Intravitreal drug delivery in retinal disease: are we out of our depth?

SS Thakur, NL Barnett, MJ Donaldson… - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: With the ever-increasing global burden of retinal disease, there is an urgent
need to vastly improve formulation strategies that enhance posterior eye delivery of …

Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model

PE Rakoczy, D Zhang, T Robertson, NL Barnett… - The American journal of …, 2002 - Elsevier
Age-related macular degeneration (AMD) is the major cause of blindness in the developed
world. Its pathomechanism is unknown and its late onset, complex genetics and strong …

Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat retina

DV Pow, NL Barnett - Neuroscience letters, 2000 - Elsevier
Excitatory amino acid transporter 5 (EAAT5) is a retina-specific glutamate transporter which
has an associated chloride conductance. Thus it is comparable in its functional properties to …

[HTML][HTML] Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys

CM Lai, WY Shen, M Brankov, YKY Lai, NL Barnett… - Molecular Therapy, 2005 - cell.com
Vascular endothelial growth factor (VEGF) is one of the major mediators of retinal ischemia-
associated neovascularization. We have shown here that adeno-associated virus (AAV) …

An open-label, noncomparative study of miglustat in type I Gaucher disease: efficacy and tolerability over 24 months of treatment

GM Pastores, NL Barnett, EH Kolodny - Clinical therapeutics, 2005 - Elsevier
BACKGROUND:: The substrate synthesis inhibitor miglustat (N-butyldeoxynojirimycin) is the
first oral agent to receive regulatory approval for the treatment of type I Gaucher disease …

[HTML][HTML] Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration

R Natoli, N Fernando, H Jiao, T Racic… - … & visual science, 2017 - tvst.arvojournals.org
Purpose: Complement system dysregulation is strongly linked to the progression of age-
related macular degeneration (AMD). Deposition of complement including C3 within the …

A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype

H Quek, J Luff, KG Cheung, S Kozlov… - Human molecular …, 2017 - academic.oup.com
Abstract Ataxia-telangiectasia (AT), an autosomal recessive disease caused by mutations in
the ATM gene is characterised by cerebellar atrophy and progressive neurodegeneration …