PEGylation is one of the most successful strategies to improve the delivery of therapeutic
molecules such as proteins, macromolecular carriers, small drugs, oligonucleotides, and …

Hyaluronic acid (HA) is a naturally-occurring glycosaminoglycan and a major component of
the extracellular matrix. Low levels of the hyaluronic acid receptor CD44 are found on the …

Some approaches to enhance the entrapment efficiency within nanoparticulate systems,
chiefly of hydrophilic molecules, developed mainly by the Turin University Pharmaceutical …

Lipids are essential components of all living cells because they are obligate components of
biological membranes, and serve as energy reserves and second messengers. Many but …

Oxaliplatin is a promising drug for cancer therapy and the oxaliplatin/5-
fluorouracil/leucovorin (FOLFOX) regimen has become the standard adjuvant treatment for …

Critically ill patients are often affected by several pathophysiological conditions requiring
antibiotic administration and, frequently, extracorporeal therapy that significantly alter the …

Among the most commonly used anticancer drugs, the alkaloids from Catharanthus roseus
(Vinca rosea) are an important tool in the medical repertoire. Vinca alkaloids, such as …

Oxidosqualene cyclase of the yeast encoded by the ERG7 gene converts oxidosqualene to
lanosterol, the first cyclic component of sterol biosynthesis. In a previous study (Athenstaedt …

Aims Subcutaneous administration of insulin in patients suffering from diabetes is
associated with the distress of daily injections. Among alternative administration routes, the …

Purpose We report for the first time the activity and safety of Unithermia®(Elmedical Ltd, Hod-
Hasharon, Israel), a novel device for administration of MMC-C with hyperthermia (HT), that …