[HTML][HTML] Pharmacogenetics of direct oral anticoagulants: a systematic review

J Raymond, L Imbert, T Cousin, T Duflot… - Journal of Personalized …, 2021 - mdpi.com
Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants
(DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics …

[HTML][HTML] Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines

C Gest, U Joimel, L Huang, LL Pritchard, A Petit… - BMC cancer, 2013 - Springer
Abstract Background Rho GTPases are involved in cellular functions relevant to cancer. The
roles of RhoA and Rac1 have already been established. However, the role of Rac3 in …

Improvement of endothelial function by chronic angiotensin-converting enzyme inhibition in heart failure: role of nitric oxide, prostanoids, oxidant stress, and …

R Varin, P Mulder, F Tamion, V Richard, JP Henry… - Circulation, 2000 - Am Heart Assoc
Background—Chronic heart failure (CHF) impairs the endothelium-dependent, flow-
mediated dilation (FMD) of small arteries. However, whether chronic angiotensin-converting …

Exercise improves flow-mediated vasodilatation of skeletal muscle arteries in rats with chronic heart failure: role of nitric oxide, prostanoids, and oxidant stress

R Varin, P Mulder, V Richard, F Tamion, C Devaux… - Circulation, 1999 - Am Heart Assoc
Background—Flow-mediated dilatation (FMD) of the peripheral arteries may be impaired in
chronic heart failure (CHF), and this could contribute to the increased peripheral resistance …

Whole blood clots are more resistant to lysis than plasma clots-greater efficacy of rivaroxaban

R Varin, SS Mirshahi, P Mirshahi, C Klein… - Thrombosis research, 2013 - Elsevier
INTRODUCTION: Defective thrombolysis, a thrombotic risk factor, can be attributed to the
formation of a compact clot poorly accessible to fibrinolytic enzymes. Venous thrombi, rich in …

Impact of recommendations on crushing medications in geriatrics: from prescription to administration

G Bourdenet, S Giraud, M Artur… - Fundamental & …, 2015 - Wiley Online Library
The practice of crushing drugs is very common in geriatric units. In 2009 a first study,
performed in all geriatric units of a university hospital, showed that numerous errors were …

[HTML][HTML] Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and …

U Joimel, C Gest, J Soria, LL Pritchard, J Alexandre… - BMC cancer, 2010 - Springer
Background Infiltration by macrophages (Mφ) indicates a poor prognosis in breast cancers,
in particular by inducing angiogenesis. Our study aimed 1) to investigate the mechanism by …

[HTML][HTML] Induction of acquired drug resistance in endothelial cells and its involvement in anticancer therapy

L Huang, C Perrault, J Coelho-Martins, C Hu… - Journal of hematology & …, 2013 - Springer
Background Multidrug resistance (MDR) is one of the major problems in the treatment of
cancer. Overcoming it is therefore expected to improve clinical outcomes for cancer patients …

The affordability of minimally invasive procedures in major lung resection: a prospective study

H Gondé, M Laurent, A Gillibert… - … and thoracic surgery, 2017 - academic.oup.com
OBJECTIVES Minimally invasive procedures are used for the surgical treatment of lung
cancer. Two techniques are proposed: video-assisted thoracic surgery or robotic-assisted …

[HTML][HTML] A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo

H Gondé, M Demeules, R Hardet, A Scarpitta… - Frontiers in …, 2021 - frontiersin.org
On murine T cells, mono-ADP ribosyltransferase ARTC2. 2 catalyzes ADP-ribosylation of
various surface proteins when nicotinamide adenine dinucleotide (NAD+) is released into …