Osteoporosis in young adults: pathophysiology, diagnosis, and management

…, ML Bianchi, JA Eisman, AJ Foldes, S Adami… - Osteoporosis …, 2012 - Springer
Postmenopausal osteoporosis is mainly caused by increased bone remodeling resulting
from estrogen deficiency. Indications for treatment are based on low areal bone mineral …

Adverse effects of bisphosphonates: a comparative review

S Adami, N Zamberlan - Drug safety, 1996 - Springer
The bisphosphonates comprise a new class of drugs, and are increasingly being used to
treat bone diseases characterised by increased osteoclastic bone resorption. These …

Involvement of WNT/β-catenin signaling in the treatment of osteoporosis

M Rossini, D Gatti, S Adami - Calcified tissue international, 2013 - Springer
Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling
(canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the …

[HTML][HTML] Denosumab for prevention of fractures in postmenopausal women with osteoporosis

…, M Austin, A Wang, S Kutilek, S Adami… - … England Journal of …, 2009 - Mass Medical Soc
Background Denosumab is a fully human monoclonal antibody to the receptor activator of
nuclear factor-κB ligand (RANKL) that blocks its binding to RANK, inhibiting the …

Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study

…, E Seeman, MC De Vernejoul, S Adami… - The journal of …, 2005 - academic.oup.com
Background: Strontium ranelate, a new oral drug shown to reduce vertebral fracture risk in
postmenopausal women with osteoporosis, was studied in the Treatment of Peripheral …

The effect of teriparatide [human parathyroid hormone (1–34)] therapy on bone density in men with osteoporosis

ES Orwoll, WH Scheele, S Paul, S Adami… - Journal of bone and …, 2003 - academic.oup.com
Abstract Teriparatide [rhPTH (1–34)] increases bone mineral density and reduces the risk of
vertebral fracture in women. We randomized 437 men with spine or hip bone mineral density …

[HTML][HTML] Effect of risedronate on the risk of hip fracture in elderly women

…, H Zippel, WG Bensen, C Roux, S Adami… - New England journal …, 2001 - Mass Medical Soc
Background Risedronate increases bone mineral density in elderly women, but whether it
prevents hip fracture is not known. Methods We studied 5445 women 70 to 79 years old who …

[HTML][HTML] Alendronate for the treatment of osteoporosis in men

…, P Miller, D Kendler, J Graham, S Adami… - … England Journal of …, 2000 - Mass Medical Soc
Background Despite its association with disability, death, and increased medical costs,
osteoporosis in men has been relatively neglected as a subject of study. There have been …

Therapeutic equivalence of alendronate 70 mg onceweekly and alendronate 10 mg daily in the treatment of osteoporosis

T Schnitzer, HG Bone, G Crepaldi, S Adami… - Aging clinical and …, 2000 - Springer
Dosing convenience is a key element in the effective management of any chronic disease,
and is particularly important in the long-term management of osteoporosis. Less frequent …

A generalized wall boundary condition for smoothed particle hydrodynamics

S Adami, XY Hu, NA Adams - Journal of Computational Physics, 2012 - Elsevier
In this paper we present a new formulation of the boundary condition at static and moving
solid walls in SPH simulations. Our general approach is both applicable to two and three …