Background Nephrotoxicity remains a problem for patients who receive cisplatin
chemotherapy. We retrospectively evaluated potential risk factors for cisplatin-induced …

Background Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the
rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the …

Background Increased motility and invasiveness of cancer cells are reminiscent of the
epithelial-mesenchymal transition (EMT), which occurs during cancer progression and …

Background Melanomas are highly malignant and have high metastatic potential; hence,
there is a need for new therapeutic strategies to prevent cell metastasis. In the present study …

Exercise enhances neuronal stem cell (NSC) proliferation and neurogenesis. However, the
effect of exercise on NSC proliferation surrounding the area of damage after traumatic brain …

Exercise is reported to inhibit neuronal apoptotic cell death in the hippocampus and improve
learning and memory. However, the effect of exercise on inhibition of neuronal apoptosis …

The tumor microenvironment plays a critical role in modulating malignant behavior and can
dramatically influence cancer treatment strategies. We investigated whether statins inhibit …

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic
inflammation of synovial joints, ultimately leading to a progressive and irreversible joint …

Objective: Previous reports have demonstrated that some focal brain injuries increase
amyloid precursor protein (APP) immunoreactivity in the region surrounding the injury in the …

Multidrug resistance represents a major obstacle for the chemotherapy of a wide variety of
human tumors. To investigate the underlying mechanisms associated with resistance to anti …