… Glucose-6-phosphatase (G-6-P) activity was used to correct for microsomal loss and DNA
recovery for cell loss. The 95% CI of the meangeo value of human MPPGL was estimated as …

The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from expression
of a gene super-family that currently contains around 1000 members in species ranging …

… A prospective study on 43 leukaemic patients also indicate that elevated transaminases are
related to high levels of methylated metabolites (P < 0.001). However, in a prospective study …

Retrospective studies have demonstrated that patients who are expressors of cytochrome
P4503A5 (CYP3A5) require a higher tacrolimus dose to achieve a therapeutic trough …

The aim of the study is to explore the contribution of genetic factors related either to drug
metabolism (cytochrome P450 2C9) or to drug target (vitamin K epoxide reductase) to variability …

… All tests were 2-sided, and a p-value of less than 0.05 was considered significant. … T 30
and P 30 correspond to the tumor DNA and plasma DNA of patient no. 30. C M and C U …

… (SNP) studied is indicated (arrows) in relation to the exon structure of the MDR1 gene
and the predicted topology of the P-glycoprotein (P-gp). (Adapted from Tanabe et al. ( 9 ).) …

Objective The aim of this work was to study simultaneously the expression profile of the 23
CYP mRNAs of CYP1, CTP2 and CYP3 families in 22 different human tissues namely adrenal …

… The number of variant 2R alleles was associated with an increasing OR of toxicity grade
3 or 4 (P trend = 0.002). An OR of 20 (95% CI, 1.5–282) was observed for patients with the …

1. Urinary excretion of 6 beta‐hydroxycortisol, hepatic microsomal cortisol 6 beta‐hydroxylase
and the specific content of several forms of cytochrome P450 were measured in 8 to 14 …