Article Text

PDF
Integrating narrow therapeutic index drug formulations in transplantation
  1. Atholl Johnston1,
  2. Liz Schick2,
  3. Teun van Gelder3
  1. 1Department of Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, London, UK
  2. 2Swisstransplant, Laupenstrasse 37, Bern, Switzerland
  3. 3Departments of Hospital Pharmacy and Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
  1. Correspondence to Professor Atholl Johnston, Department of Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK; a.johnston{at}qmul.ac.uk

Abstract

There is considerable debate regarding generic drug substitution in solid organ transplant recipients, and various European transplant associations and societies have expressed caution about the potential adverse consequences from uncontrolled switching between the different narrow therapeutic index drug (NTID) formulations now available to the physician and pharmacist. This issue was discussed the 17th Congress of the EAHP, Milan, Italy. The Astellas-sponsored symposium, chaired by Professor Atholl Johnston (Professor of Clinical Pharmacology, Barts and The London School of Medicine and Dentistry, UK), explored the risks and benefits of switching between alternative NTID formulations, and outlined current European recommendations. Professor Johnston introduced the symposium, highlighting the severe shortage of organ donors across all organ categories in Europe, and the fact that every donated organ represents a gift, either by the family of the deceased or by the living donor. Consequently, it is essential to make optimal use of organs and not waste this precious resource.

View Full Text

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.